Endocrinology Research and Practice
Original Article

Subclinical Hypothyroidism is Associated with Atherogenic Lipid Profile in Postmenopausal Women

1.

Clinical Center University Sarajevo Medical Intensive Care Unit Sarajevo BA

2.

Clinical Center University of Sarajevo Clinic for Nuclear Medicine and Endocrinology Sarajevo BA

3.

Clinical Center University of Sarajevo Clinic for Cardiology, Rheumatology and Vascular Disease Sarajevo BA

4.

Clinical Center University of Sarajevo Clinic for Anesthesiology and Reanimation Sarajevo BA

Turk J Endocrinol Metab 2017; 21: 37-41
DOI: 10.25179/tjem.2017-56539
Read: 591 Downloads: 154 Published: 01 June 2017

ABSTRACT

Purpose: To determine the prevalence and association of atherogenic lipid profile in postmenopausal women with subclinical hypothyroidism.

Materials (Subjects) and Methods: This as a prospective clinical study included 140 postmenopausal women. In all subjects, basic sociodemographic and anthropometric data, hormonal status of the thyroid gland, and lipid profile were determined. The subjects were followed for a period of 30 months.

Results: The subclinical hypothyroidism in postmenopausal women was significantly associated with higher levels of serum cholesterol, triglycerides, LDL-C, and lower HDL-C (p=0.009, p=0.01, p=0.023, p=0.001, respectively). Furthermore, the analysis of repeated measures showed that subclinical hypothyroidism, irrespective of age and duration of postmenopause, was associated with higher levels of serum cholesterol (adjusted beta: 0.43, CI: 0.12, 0.74, p=0.007), triglycerides (adjusted beta: 0.52, CI: 0.21, 0.84, p=0.001) and LDL-C (adjusted beta: 0.35, CI: 0.03, 0.67, p=0.03), and lower levels of serum HDL-C (adjusted beta: -0.48, CI: -0.81, 0.15, p=0.004)

Conclusion: Subclinical hypothyroidism is associated with atherogenic lipid profile in postmenopausal women.

 

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