Turkish Journal of
Endocrinology and Metabolism
Original Article

Subclinical Hypothyroidism is Associated with Atherogenic Lipid Profile in Postmenopausal Women

1.

Clinical Center University Sarajevo Medical Intensive Care Unit Sarajevo BA

2.

Clinical Center University of Sarajevo Clinic for Nuclear Medicine and Endocrinology Sarajevo BA

3.

Clinical Center University of Sarajevo Clinic for Cardiology, Rheumatology and Vascular Disease Sarajevo BA

4.

Clinical Center University of Sarajevo Clinic for Anesthesiology and Reanimation Sarajevo BA

Turk J Endocrinol Metab 2017; 21: 37-41
DOI: 10.25179/tjem.2017-56539
Read: 41 Downloads: 14 Published: 01 June 2017

ABSTRACT

Purpose: To determine the prevalence and association of atherogenic lipid profile in postmenopausal women with subclinical hypothyroidism.

Materials (Subjects) and Methods: This as a prospective clinical study included 140 postmenopausal women. In all subjects, basic sociodemographic and anthropometric data, hormonal status of the thyroid gland, and lipid profile were determined. The subjects were followed for a period of 30 months.

Results: The subclinical hypothyroidism in postmenopausal women was significantly associated with higher levels of serum cholesterol, triglycerides, LDL-C, and lower HDL-C (p=0.009, p=0.01, p=0.023, p=0.001, respectively). Furthermore, the analysis of repeated measures showed that subclinical hypothyroidism, irrespective of age and duration of postmenopause, was associated with higher levels of serum cholesterol (adjusted beta: 0.43, CI: 0.12, 0.74, p=0.007), triglycerides (adjusted beta: 0.52, CI: 0.21, 0.84, p=0.001) and LDL-C (adjusted beta: 0.35, CI: 0.03, 0.67, p=0.03), and lower levels of serum HDL-C (adjusted beta: -0.48, CI: -0.81, 0.15, p=0.004)

Conclusion: Subclinical hypothyroidism is associated with atherogenic lipid profile in postmenopausal women.

Subklinik Hipotiroidizm Menopoz Sonrasında Aterojenik Lipid Profiliyle İlişkilidir

ÖZET

Amaç: Subklinik hipotirodizmi olan postmenopozal kadınlarda aterojenik lipid profilinin prevalansını ve ilişkisini belirlemektir.

Gereç (Olgular) ve Yöntemler: Prospektif klinik çalışma 140 postmenopozal kadını içermiştir. Tüm olgularda temel sosyodemografik ve antropometrik verileri, tiroid bezinin hormonal durumu ve lipid profili belirlenmiştir. Olgular 30 ay süreyle takip edilmiştir.

Bulgular: Postmenopozal kadınlarda subklinik hipotiroidizm daha yüksek serum kolesterol, trigliserid, LDL-C düzeyleri ve daha düşük HDLC düzeyleriyle anlamlı düzeyde ilişkilidir (sırasıyla, p=0,009, p=0,01, p=0,023, p=0,001). Dahası, tekrarlanan ölçümlerin analizleri subklinik hipotiroidizmin, yaş ve menopoz süresinden bağımsız olarak; daha yüksek serum kolesterol (uyarlanmış beta: 0,43, CI: 0,12, 0,74, p=0,007), trigliserid (uyarlanmış beta: 0,52, CI: 0,21, 0,84, p=0,001) ve LDL-C (uyarlanmış beta: 0,35, CI: 0,03, 0,67, p=0,03) ve daha düşük serum HDLC (uyarlanmış beta: -0,48, CI: -0,81, 0,15, p=0,004) düzeyleriyle ilişkili olduğunu göstermiştir.

Sonuç: Subklinik hipotiroidizm postmenopozal kadınlarda aterojenik lipid profiliyle ilişkilidir.

Keywords: Subklinik hipotiroidizm; aterojenik lipid profili; postmenopozal

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TURKISH
ISSN 1301-2193 EISSN 1308-9846