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ABSTRACT
Macromolecular form of prolactin is generally associated with asymptomatic hyperprolactinemia. Increases in molecular size may result from self-aggregation or binding with antiprolactin antibodies. Such a benign clinically insignificant laboratory abnormality could be documented by gel filtration chromatography, polyethylene glycol precipitation methods or directly detecting antiprolactin autoantibody itself. Here we report a case of asymptomatic hyperprolactinemia due to macroprolactinemia associated with prolactin autoantibodies to notice the importance of clinically insignificant isolated laboratory abnormalities.
Macromolecular form of prolactin is generally associated with asymptomatic hyperprolactinemia. Increases in molecular size may result from self-aggregation or binding with antiprolactin antibodies. Such a benign clinically insignificant laboratory abnormality could be documented by gel filtration chromatography, polyethylene glycol precipitation methods or directly detecting antiprolactin autoantibody itself. Here we report a case of asymptomatic hyperprolactinemia due to macroprolactinemia associated with prolactin autoantibodies to notice the importance of clinically insignificant isolated laboratory abnormalities.