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ABSTRACT
The effect of acetyl salicylic acid (ASA) on thyroid function is a well known phenomenon. This effect is due to competative inhibition of hormone binding to thyroid binding globulin which results in elevation of free components of hormones in serum, in this study, the purpose is to assess the effects of nonsteroidal anti-inflamatory drugs (NSAİDs) except ASA, on thyroid function tests and TSH response to TRH stimulation. Eighteen patients receiving NSAİDs because of osteoarthrosis were studied.17 of all patients were male and one was female. Median age was 47.2±11.8 years (from 39 to 60). Thyroid function tests and TRH stimulation tests were performed at the beginning , first and third weeks of the study for observing the early and late effect of NSAİDs. According to our findings; naproxe, indomethacin and diflunisal had no effect on thyroid functions and TSH response to TRH stimulation neither at the beginning nor at the first and third weeks of the study. Although tenoxicam had no effect on thyroid functions (for all periods), TSH response to TRH at the 30th and 6Ûth minutes were significantly elevated at the third stimulation. Result: Commonly prescribed NSAİDs especially naproxen sodium, indomethacin and diflunisal seems to have no effect on thyroid function tests and TSH response to TRH stimulation. Another NSAID, tenoxicam, which has a long halt life, may affect TSH response to TRH stimulation.
The effect of acetyl salicylic acid (ASA) on thyroid function is a well known phenomenon. This effect is due to competative inhibition of hormone binding to thyroid binding globulin which results in elevation of free components of hormones in serum, in this study, the purpose is to assess the effects of nonsteroidal anti-inflamatory drugs (NSAİDs) except ASA, on thyroid function tests and TSH response to TRH stimulation. Eighteen patients receiving NSAİDs because of osteoarthrosis were studied.17 of all patients were male and one was female. Median age was 47.2±11.8 years (from 39 to 60). Thyroid function tests and TRH stimulation tests were performed at the beginning , first and third weeks of the study for observing the early and late effect of NSAİDs. According to our findings; naproxe, indomethacin and diflunisal had no effect on thyroid functions and TSH response to TRH stimulation neither at the beginning nor at the first and third weeks of the study. Although tenoxicam had no effect on thyroid functions (for all periods), TSH response to TRH at the 30th and 6Ûth minutes were significantly elevated at the third stimulation. Result: Commonly prescribed NSAİDs especially naproxen sodium, indomethacin and diflunisal seems to have no effect on thyroid function tests and TSH response to TRH stimulation. Another NSAID, tenoxicam, which has a long halt life, may affect TSH response to TRH stimulation.