Endocrinology Research and Practice
Original Article

Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia


Department of Endocrinology and Metabolism, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey


Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey


Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey

Endocrinol Res Pract 2022; 26: 115-119
DOI: 10.5152/tjem.2022.22068
Read: 798 Downloads: 223 Published: 06 September 2022

Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years. Klotho is an anti-aging transmembrane glycoprotein with growth hormone and insulin-like growth factor-1-related effects. Both kisspeptin and klotho seem to interact with prolactin in the hypothalamic-pituitary region. In this study, we aimed to investigate the relationship between hyperprolactinemia and circulating kisspeptin and klotho levels.

Methods: In this study, 33 women with hyperprolactinemia and 28 control subjects were included. Blood samples were analyzed for follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, α-klotho, kisspeptin, and neurokinin B levels.

Results: There was no difference between the groups in terms of kisspeptin and α-klotho levels (P =.68 and P =.11, respectively). Follicle-stimulating hormone and estradiol were significantly lower in the hyperprolactinemia group (P =.02 and P =.03, respectively). Kisspeptin levels were positively correlated with follicle-stimulating hormone levels (r=0.43, P =.01) and α-klotho levels (r =  0.32, P =.01). Neurokinin B was negatively correlated with both kisspeptin and α-klotho values (r = −0.42, P =.01 and r =−0.29, P =.02, respectively). Body mass index was positively correlated with kisspeptin and negatively correlated with α-klotho molecule (r = 0.273, P =.03 and r =−0.25, P =.04, respectively).

Conclusion: Hyperprolactinemia does not affect circulating kisspeptin and α-klotho levels but positively correlates with kisspeptin and α-klotho, which are known to play a role in complex interactions between the hypothalamus and the pituitary that may be the subject of new studies in the future.

Cite this article as: Arslan İE, Olcay Öztürk B, Bolayır B, Yalçın MM, Yetkin İ, Aktürk M. Circulating kisspeptin and klotho levels in women with hyperprolactinemia. Turk J Endocrinol Metab. 2022;26(3):115-119.

EISSN 2822-6135