Turkish Journal of
Endocrinology and Metabolism
Orijinal Araştırma

Efficacy of Multidisciplinary Approach in Thyroid Nodules: Analysis of Factors Used for Predicting Malignancy

1.

Department of Endocrinology, İstinye University Faculty of Health Sciences, Yıldızlı Medicalpark Hospital, Trabzon, Turkey

2.

Department of Internal Medicine, Karadeniz Technical University, Trabzon, Turkey

3.

Department of Pathology, Karadeniz Technical University, Trabzon, Turkey

4.

Department of Radiology, Karadeniz Technical University, Trabzon, Turkey

5.

Department of Public Health, Rize Provincial Health Institution, Rize, Turkey

6.

Department of Endocrinology, Karadeniz Technical University, Trabzon, Turkey

Turk J Endocrinol Metab 2022; 26: 125-130
DOI: 10.5152/tjem.2022.22020
Okunma: 613 İndirilme: 157 Online Yayın Tarihi: 06 Eylül 2022

Objective: To date, numerous molecular tests have been developed for preoperative evaluation of thyroid nodules. Nevertheless, these tests cannot be administered in many centers due to their imprecise diagnoses and high costs. The present study aimed to investigate the effect of making surgical decisions in a panel through a multidisciplinary approach after clinical, ultrasonographic, and pathological evaluation of nodules on the accuracy of the decisions.

Methods: The retrospective study included patients with thyroid nodules who underwent preoperative ultrasonography followed by fine-needle aspiration biopsy, which was confirmed by postoperative pathological examinations between January 2017 and January 2019. The relationship between ultrasonography features of nodules and malignancy was analyzed. A comparison was performed between patients who were referred for surgery through the multidisciplinary versus non-multidisciplinary approach.

Results: A total of 255 nodules in 211 patients were evaluated in the study. The prevalence of malignancy was 100% in nodules with hypoechogenicity+microcalcification+margin irregularity (P < .001). The likelihood of malignancy was significantly higher in dual combinations of these 3 adverse conditions (P < .001 for all). Margin irregularity was found to be the most predictive model for malignancy (CI: 1.9-13.8, odds ratio: 5.249, P < .001). The multidisciplinary approach was superior to the non-multidisciplinary approach in the detection of malignancy (P=.008).

Conclusion: Margin irregularity had the highest predictive value for the detection of malignancy. Employing the multidisciplinary approach in preoperative evaluation of thyroid nodules can be highly effective in detecting malignancy and preventing unnecessary surgery.

Cite this article as: Kişioğlu SV, Atacan H, Çakır E, Oğuz Ş, Karakullukçu S, Ersöz HÖ. Efficacy of multidisciplinary approach in thyroid nodules: Analysis of factors used for predicting malignancy. Turk J Endocrinol Metab. 2022;26(3):125-130.

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