A natural anti-coagulant AT III plays a defensive role against intravascular coagulation and regulates blood hemostasis. Diabetes is associated with hypercoagulable state. The level of blood AT III levels in the Turkish diabetic population have been studied. 100 diabetic patients (2 type 1, 75 type 2) and 20 healthy control were included in the study. AT III levels were 34.75 mg/dl in healthy control, and 41.89 mg/dl in the diabetic group (p<0.0001). There was no difference between type 1 and type 2 diabetics (p=0.16). This study showed that serum AT III levels increased in both type 1 and type 2 diabetics. The level of AT III did not have any correlation with duration of diabetes, blood glucose, HbA1c, lipid levels and diabetic complications (p>0.05). Treatment type (diet, oral anti-diabetics and insulin) did not affect AT III levels (p>0.05).
Keywords: Antithrombin III, diabetes mellitus