ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism

In this study, we evaluated the effect of thyroxine treatment on bone mineral density in premenopausal women with thyroid nodules. Twenty women were accepted for this study. L-thyroxine was started at a dose of 100 g/day by oral route for a 6-month period. Before and after the treatment bone mineral densities of the femur neck and AP spine were measured. Paired-t test and ANOVA were used in statistical analysis. Serum TSH levels of the patients were found to be within the normal range at the 1st, 2nd, 3rd, 4th , 5th and 6th months. But serum TSH levels at these months decreased with the treatment when compared to basal levels (Basal 1.96±0.77, 6 th month 0.23±0.05 and p=0.0001). On the contrary, bone mineral density (BMD) and Z-scores of the femur neck and vertebra of the patients did not show any significant change (basal BMD is 1.02±0.10 in femur neck and 1.11±0.11 in vertebra. Bone mineral density was 1.10±0.08 in femur neck and 1.14±0.12 in vertebra at 6 th month). Conclusions; treatment of benign thyroid nodules with L-thyroxine leads to hyperthyroidism. L-thyroxine treatment affected neither BMD nor Z-score.
Keywords: Bone mineral density, thyroxine, TSH and benign thyroid nodule