Thirty-Four Patients with Cushing’s Syndrome: Our Clinical Experience in the Past 20 Years - Original Article
Mehtap Evran, Murat Sert, Tamer Tetiker
Abstract Objective: Cushing’s syndrome is a relatively rare disorder caused by chronic endogenous hypercortisolemia. We aimed to present patients with Cushing’s syndrome who were diagnosed and followed at our endocrinology clinic. Materials and Methods: 34 patients (26 female, 8 male) with Cushing’s syndrome were enrolled in this retrospective study. Results: Of 34 patients, 20 had Cushing’s disease and 14 had Cushing’s syndrome. Regarding the clinical signs of Cushing’s syndrome, purple striae were present in 31 subjects (91.2%), hirsutismus in 21 (72.4 %), buffalo hump in 33 (97.1%), moon face in 33 (%97.1), plethora in 33 (%97.1), and menstrual irregularities in 21 (84%) subjects. Diabetes mellitus (DM), hypertension and osteoporosis were found to be 13/34 (39.4%), 23/34 (69.7%) and 18/34 (66.7%), respectively. Following the treatment, primary adrenal failure, secondary adrenal failure, central hypothyroidism, central hypogonadism and central diabetes insipidus were found to be 3 (8.8%), 3 (8.8%), 4 (11.7%), 4 (11.7%) and 4 (11.7%), respectively. Conclusions: As reported in the literature, Cushing's disease is the most common form of Cushing’s syndrome and various complications such as adrenal failure, hypogonadism, diabetes insipidus can develop following the treatment. Turk Jem 2009; 13: 75-9 Key words: Cushing’s syndrome, Cushing’s disease, hypercortisolemia
Özet Amaç: Cushing’s sendromu nadir görülen, kronik endojen hiperkortizoleminin yol açtığı morbid bir hastalıktır. Biz kliniğimizde tanı konulan ve takip edilen 34 Cushing ‘s sendromlu hastayı sunmayı amaçladık. Gereç ve Yöntemler: Bu retrospektif çalışmaya 34 (26 kadın, 8 erkek) Cushing ‘s sendromlu hasta dahil edildi. Bulgular: Otuz dört hastanın 20‘si Cushing’s hastalığı, 14’ü Cushing’s sendromu tanısı aldı. Cushing’s sendromunun klinik bulgularından, mor strialar 31 (%91,2), hirsutismus 21 (%72,4 ), buffalo hump 33 (%97,1), aydede yüzü 33 (%97,1), pletore 33 (%97,1) ve adet düzensizliği 21 (%84) hastada görüldü. Diyabetes mellitus (DM), hipertansiyon ve osteoporoz sırasıyla 13/34 (%39,4), 23/34 (%69,7) ve 18/34 (%66,7) hastada bulundu. Tedavi sonrasında takiplerde primer adrenal yetmezlik, sekonder adrenal yetmezlik, santral hipotroidizm, santral hipogonadizm ve santral diyabetes insipidus oranları sırasıyla 3 (%8,8), 3 (%8,8), 4 (%11,7), 4 (%11,7) ve 4 (%11,7) olarak saptandı. Sonuç: Literatürle uyumlu olarak, Cushing’s hastalığı Cushing’s sendromunun en çok görülen şeklidir ve tedavi sonrası farklı komplikasyonlar, örneğin; adrenal yetmezlik, hipogonadizm, diyabetes insipidus gelişebilir. Türk Jem 2009; 13: 75-9 Anahtar kelimeler: Cushig's sendromu, Cushing's hastalığı, hiperkortizolemi
, Murat Sert
