Trabzon Numune Training and Research Hospital, Department of Endocrinology and Metabolism, Trabzon, Turkey
Leyla Yılmaz Gürbüz;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Filiz Sürücü;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Ali Said Turgut;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Neşe Özbey;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Adil Azezli;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Ferihan Aral;
University of İstanbul, İstanbul School of Medicine, Division of Endocrinology and Metabolism, İstanbul, Turkey
Yusuf Orhan;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Ergin Sencer;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Senay Molvalılar;
Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Istanbul Faculty of Medicine, Capa, 34390, Istanbul, Turkey
Trabzon Numune Training and Research Hospital, Department of Endocrinology and Metabolism, Trabzon, Turkey
Hypopituitarism is a disorder of diverse etiology that results in partial or total loss of pituitary functions. Here we report a 49-year-old female patient presenting with absence of peripheral pulses of the right upper extremity and anterior pituitary failure. She was initially diagnosed as Sheehan's syndrome in 1974 and Takayasu arteritis in 1990. But she was found to be positive for factor V Leiden mutation in 1990. We suggest that this mutation, which causes resistance to activated protein C and is an established risk factor for thrombosis, also is the cause for both the ischemic necrosis of the pituitary and subclavian artery occlusion in our case.
Keywords: Hypopituitarism, factor V Leiden mutation
Hypopituitarism is a disorder of diverse etiology that results in partial or total loss of pituitary functions. Here we report a 49-year-old female patient presenting with absence of peripheral pulses of the right upper extremity and anterior pituitary failure. She was initially diagnosed as Sheehan's syndrome in 1974 and Takayasu arteritis in 1990. But she was found to be positive for factor V Leiden mutation in 1990. We suggest that this mutation, which causes resistance to activated protein C and is an established risk factor for thrombosis, also is the cause for both the ischemic necrosis of the pituitary and subclavian artery occlusion in our case.
Keywords: Hypopituitarism, factor V Leiden mutation
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