ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
ORIGINAL ARTICLE

Relationship Between Leptin to Adiponectin Ratio and Metabolic Syndrome Indices in Apparently Healthy Adults
Görünüşte Sağlıklı Olan Erişkinlerde Leptin-Adiponektin Oranı ile Metabolik Sendrom İndeksleri Arasındaki İlişki
Received Date : 17 Jul 2019
Accepted Date : 18 Mar 2020
Available Online : 29 Mar 2020
Doi: 10.25179/tjem.2019-70761 - Makale Dili: EN
Turk J Endocrinol Metab 2020;24:122-131
Bu makale, CC BY-NC-SA altında lisanslanmış açık erişim bir makaledir.
ABSTRACT
Objective: Leptin/adiponectin (L/A) ratio is considered a predicting factor of metabolic syndrome (MetS) and its related morbidities. In the present study, we determined the association of serum L/A ratio with MetS parameters in apparently healthy Iranian adults. Material and Methods: This cross-sectional study was conducted on 150 apparently healthy adults aged 25 to 50 years, who were selected by random sampling from different medical centers of Tabriz city, Iran. Our criteria for being a healthy individual were based on self-report of the participants. Anthropometric measures, fasting blood sugar (FBS) and lipid profile, systolic and diastolic blood pressure (SBP and DBP), and fasting serum L/A levels were measured. Results: There were significant differences (p<0.05) in weight, height, waist circumference (WC), SBP, triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), serum leptin concentration, and L/A ratio between males and females. Univariate linear regression model revealed a significant positive association of serum leptin concentration with WC (p=0.024) and FBS (p=0.046). A similar result was obtained using the multiple regression model after adjusting for confounding factors (p<0.001 and p=0.045). A significant positive correlation was found between the L/A ratio and WC (p=0.010) in the adjusted model. However, no significant association was observed between adiponectin and MetS indices. Conclusion: Our findings indicated a significant positive association of serum leptin concentration with WC and FBS and between L/A ratio and WC in apparently healthy adults. Therefore, compared to adiponectin, leptin, and L/A ratio could be useful predictors of MetS.
ÖZET
Amaç: Leptin/adiponektin (L/A) oranı, metabolik sendrom (MetS) ve bununla ilişkili morbiditeler için öngördürücü bir faktör olarak kabul edilir. Bu çalışmada, görünüşte sağlıklı olan İranlı erişkinlerde serum L/A oranının MetS parametreleri ile ilişkisini inceledik. Gereç ve Yöntemler: Kesitsel tipteki bu çalışma, İran'ın Tebriz şehrindeki farklı tıp merkezlerinden rastgele örnekleme ile seçilen, 25-50 yaşları arasında bulunan ve görünüşte sağlıklı olan 150 erişkin üzerinde gerçekleştirildi. Sağlıklı bir birey olma kriterimiz, katılımcıların kendi beyanlarına dayandırıldı. Antropometrik ölçümler, açlık kan şekeri (AKŞ) ve lipit profili, sistolik ve diyastolik kan basıncı (SKB ve DKB) ve açlık serum L/A düzeyleri ölçüldü. Bulgular: Erkekler ve kadınlar arasında ağırlık, boy, bel çevresi (BÇ), SKB, trigliserit (TG), yüksek- dansiteli lipoprotein-kolesterol (HDL-K), serum leptin konsantrasyonu ve L/A oranı açısından anlamlı farklılıklar (p<0,05) vardı. Tek değişkenli doğrusal regresyon modeli, serum leptin konsantrasyonunun BÇ (p=0,024) ve AKŞ (p=0,046) ile anlamlı bir pozitif ilişkisi olduğunu ortaya koydu. Karıştırıcı faktörler ayarlandıktan sonra çoklu regresyon modeli kullanılarak benzer bir sonuç elde edildi (p<0,001 ve p=0,045). Ayarlanan modelde, L/A oranı ile BÇ (p=0,010) arasında anlamlı pozitif korelasyon bulundu. Ancak, adiponektin ve MetS indeksleri arasında anlamlı bir ilişki gözlenmedi. Sonuç: Bulgularımız, görünüşte sağlıklı olan erişkinlerde serum leptin konsantrasyonu ile BÇ-AKŞ ve L/A oranı-BÇ arasında anlamlı pozitif ilişki olduğunu gösterdi. Yani, adiponektin ile karşılaştırıldığında, leptin ve L/A oranı MetS için daha yararlı öngördürücüler olabilir.
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