ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
ORIGINAL ARTICLE

Platelet Activation is a Risk Factor for Obesity
Trombosit Aktivasyonu Obezite İçin Bir Risk Faktörüdür
Received Date : 20 Dec 2019
Accepted Date : 20 Feb 2020
Available Online : 29 Mar 2020
Doi: 10.25179/tjem.2019-72995 - Makale Dili: EN
Turk J Endocrinol Metab. 2020;24:132-137
Bu makale, CC BY-NC-SA altında lisanslanmış açık erişim bir makaledir.
ABSTRACT
Objective: Obesity is known to be a triggering factor for many chronic diseases. Blood parameters, especially platelet (PLT)-related factors, have gained importance for a better understanding of obesity. In this study, we investigated the correlation between PLT-related parameters and bodily factors to enhance our knowledge of this important area of research. Material and Methods: Consenting volunteers between 18 and 65 years were included in the study. Their heights, weights, body mass indices (BMI), fat percentages, fat masses (FM), and fat-free masses (FFM) were determined. Fat mass index (FMI=fat mass/height m2) and fat-free mass index (FFMI=fat free mass/height m2) were calculated. Blood samples were taken to determine the parameters such as PLT, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). Results: In males, PLT increased with weight, fat percentage, FM, and FMI. However, there was no change in PCT values with these parameters. In females, PLT decreased with age, increased with weight, BMI, fat percentage, FM, FFM, and FMI. PCT increased with weight, BMI, fat percentage, FM, FFM, and FMI. Conclusion: A significant relationship between PLT activation and body fat content was observed in both genders in the present study. Thus, these blood parameters can be a useful tool for investigating inflammation- related complications in obese individuals. It is speculated that obese individuals may be encouraged toward becoming thrombocyte apheresis donors to reduce their PLT counts, which may lead to a decrease in the risk of obesity-related inflammation in such individuals.
ÖZET
Amaç: Obezitenin birçok kronik hastalığı tetiklediği bilinmektedir. Kan parametrelerinden özellikle trombositler [platelets (PLTs)] ile ilgili olan parametrelerin obeziteyle ilişkisi üzerine yapılan çalışmalar önem kazanmaya başlamıştır. Bu çalışmada amacımız, obezitede yağ dokusu artışının PLT parametreleri ile ilişkisini ortaya koymaktır. Gereç ve Yöntemler: Polikliniğimize obezite nedeni ile başvuran 18-65 yaş arası bireyler çalışmaya dahil edildi. Çıplak ayakla boy uzunlukları ölçüldükten sonra biyoimpedans cihazı ile yağ analizi yapılarak kilo, beden kitle indeksi (BKİ), yağ yüzdesi,yağ ağırlığı ve yağsız ağırlık tespit edildi. Yağ ağırlığı indeksi [fat mass index (FMI)/height m2] ve yağsız ağırlık indeksi [fat free mass (FFMI)/height m2] hesaplandı. Kan bulgularına ulaşılarak PLT, ortalama trombosit hacmi [mean platelet volume (MPV)], trombosit dağılım genişliği [platelet distribution width (PDW)] ve “plateletcrit (PCT)” değerleri belirlendi. Bulgular: Trombosit sayısının erkeklerde kilo, yağ yüzdesi, yağ ağırlığı ve FMI ile arttığı fakat PCT'nin değişmediği tespit edildi. Kadınlarda ise PLT sayısının yaşla orantılı azaldığı, ancak kilo, BKİ, yağ yüzdesi, yağ ağırlığı, FFM ve FMI ile orantılı olarak arttığı tespit edildi. PCT’nin kilo, BKİ, yağ yüzdesi, yağ ağırlığı, FFM ve FMI ile arttığı tespit edildi. Sonuç: Her iki cinste PLT aktivasyonu ile vücut yağ dokusu arasında bir ilişkinin olduğunun tespit edilmiş olması, kolaylıkla ulaşılması mümkün olan kan parametrelerinin obezitenin inflamasyonla ilişkili komplikasyonlarının takibinde kullanılabileceğini düşündürmektedir. Ayrıca obez kişileri PLT aferez vericisi olarak yönlendirme ve cesaretlendirmenin de PLT sayısını azaltarak inflamasyonla ilişkili komplikasyonları önlemede etkili olabileceği yönünde düşünülebilir.
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