ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
ORIGINAL ARTICLE

Lower Levels of Osteoprotegerin in Subjects with Arterial Calcification and an Inverse Correlation Between Osteoprotegerin and Lipoprotein (a) Levels - Original Article
Lower Levels of Osteoprotegerin in Subjects with Arterial Calcification and an Inverse Correlation Between Osteoprotegerin and Lipoprotein (a) Levels - Original Article
Makale Dili: EN
ABSTRACT

Summary

Osteoporosis an d vascular disease are common and important causes of morbidity and mortality in elderly people. We aimed to evaluate serum osteoprotegerin (OPG) levels and their correlation with radial artery calcification and lipid profile in 36 patients undergone coronary artery bypass graft surgery. We found radial artery calcification in 4 subjects and all had medial calcification. OPG levels of subjects with arterial calcification were significantly lower than subjects without arterial calcification (184.06 ± 18.30 vs 86.25 ± 13.79 pg/mL; p = 0.044). We did not observe any significant difference between the groups regarding age, sex, body mass index, hypertension, diabetes mellitus, glucose metabolism, lipid profile, smoking and alcohol intake. There was an inverse correlation between OPG and lipoprotein {Lp}(a) levels (r = -0.567; p < 0.0001). This inverse correlation was seen in both diabetic and non-diabetic subjects (r = -0.522; p = 0.031 and r = -0.597; p = 0.007). As a conclusion, in patients with coronary artery disease (CAD), OPG levels are lower in subjects with radial arterial calcification than in subjects without radial arterial calcification and there is an inverse correlation between OPG and Lp(a). Therefore, OPG may play an important role in arterial calcification and endothelial dysfunction.
Keywords: Osteoprotegerin, arterial calcification, lipoprotein (a), coronary artery bypass graft surgery

ÖZET

Summary

Osteoporosis an d vascular disease are common and important causes of morbidity and mortality in elderly people. We aimed to evaluate serum osteoprotegerin (OPG) levels and their correlation with radial artery calcification and lipid profile in 36 patients undergone coronary artery bypass graft surgery. We found radial artery calcification in 4 subjects and all had medial calcification. OPG levels of subjects with arterial calcification were significantly lower than subjects without arterial calcification (184.06 ± 18.30 vs 86.25 ± 13.79 pg/mL; p = 0.044). We did not observe any significant difference between the groups regarding age, sex, body mass index, hypertension, diabetes mellitus, glucose metabolism, lipid profile, smoking and alcohol intake. There was an inverse correlation between OPG and lipoprotein {Lp}(a) levels (r = -0.567; p < 0.0001). This inverse correlation was seen in both diabetic and non-diabetic subjects (r = -0.522; p = 0.031 and r = -0.597; p = 0.007). As a conclusion, in patients with coronary artery disease (CAD), OPG levels are lower in subjects with radial arterial calcification than in subjects without radial arterial calcification and there is an inverse correlation between OPG and Lp(a). Therefore, OPG may play an important role in arterial calcification and endothelial dysfunction.
Keywords: Osteoprotegerin, arterial calcification, lipoprotein (a), coronary artery bypass graft surgery