ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
CASE REPORT

Granulomatosis Polyangiitis Presented with Diabetes Insipidus
Granülomatöz Polianjitisin Nadir Bir Tutulumu: Diabetes İnsipidus Olgusu
Received Date : 29 Sep 2019
Accepted Date : 03 Feb 2020
Available Online : 14 Feb 2020
Doi: 10.25179/tjem.2019-71445 - Makale Dili: EN
Turk J Endocrinol Metab 2020;24:96-100
Bu makale, CC BY-NC-SA altında lisanslanmış açık erişim bir makaledir.
ABSTRACT
The pathogenesis of granulomatosis polyangiitis (GPA), systemic vasculitis of small and medium-size vessels, is not completely understood. GPA mainly affects the upper and lower respiratory tract. However, it may involve the central nervous system (CNS) as well. The most common manifestation of CNS involvement is necrotizing vasculitis, leading to peripheral neuropathies or cranial nerve palsy. CNS disorder is less common. CNS involvement in GPA can manifest itself in three ways: Vasculitic involvement, granuloma spread from adjacent anatomical areas, and new granuloma formation in brain tissue. We present a case of GPA presented with diabetes insipidus.
ÖZET
Granülomatöz polianjitis (GPA), küçük ve orta ölçekli damarların sistemik bir vaskülitidir. Patogenezi tam olarak anlaşılamamıştır. Başlıca üst ve alt solunum yollarını etkiler. Ancak, sinir sistemi tutulumu da söz konusudur. En sık olarak, periferal nöropatilere veya kraniyal sinir felcine yol açan nekrotizan vaskülit olarak kendini gösterir. Santral sinir sistemi (SSS) bozukluğu daha az sıklıkta görülür. SSS tutulumu 3 şekilde olabilir: Vaskülitik tutulum, komşu anatomik alanlardan granülom yayılımı ve beyin dokusunda yeni granülom oluşumu. Biz bu olgumuzda, diabetes inspidus ile prezante olan bir GPA vakası sunduk.
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