ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
ORIGINAL ARTICLE

Fine Needle Aspiration Biopsy in The Evaluation of Nodular Thyroid Disease - Original Article
Fine Needle Aspiration Biopsy in The Evaluation of Nodular Thyroid Disease - Original Article
Makale Dili: EN
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ABSTRACT

Distinguishing between benign and malignant lesions in patients with thyroid nodules is essential to avoid a large number of unnecessary operations. Fine needle aspiration biopsy (FNAB) has become a popular technique in the evaluation of patients with thyroid nodules. This report describes our experience with FNAB technique the role of FNAB, radionuclide imaging and ultrasound In the initial evaluation of the patient and determines the accuracy of aspiration cytology. 968 fine needle aspiration biopsies from 781 patients were performed and 123 of them were operated. Cytological diagnosis of all FNAB is shown below: malignant lesions 17 (1.8 %), Hashimoto thyroiditis 20 (2.1 %), subacute thyroiditis 5 (0.5 %), suspicious follicular proliferation 6 (0.6 %), inadequate specimen 165 (17.0 %) and other benign lesions 755 (80-0 %). Sampling errors and cytodiagnostic errors were calculated as 7,7 % (9/123) and 4.0 % (5/123) respectively. Rates are calculated as false positive 33 %, false negative 3 %, sensitivity 77 %, specificity 95 %, positive predictive value 67 %, negative predictive value 53 % and accuracy 93 %. The technical success, sensitivity, positive predictive value and accuracy rates in our series are compatible with the literature but not in perfect ranges. Our results confirm the accuracy of FNAB in the diagnosis of thyroid malignancies. The primary shortcomings consist of difficulty in obtaining representative smears of the lesion at aspiration and a small number of inaccurate results in predicting the specific histological diagnosis. initial examination by ultrasound and radionuclide imaging results showed that cystic and hot nodules had a lower occurrence of malignant lesions but they were not always benign.
Keywords: Fine needle aspiration biopsy, thyroid nodule, thyroidectomy, ultrasonography, radionuclide imaging

ÖZET

Distinguishing between benign and malignant lesions in patients with thyroid nodules is essential to avoid a large number of unnecessary operations. Fine needle aspiration biopsy (FNAB) has become a popular technique in the evaluation of patients with thyroid nodules. This report describes our experience with FNAB technique the role of FNAB, radionuclide imaging and ultrasound In the initial evaluation of the patient and determines the accuracy of aspiration cytology. 968 fine needle aspiration biopsies from 781 patients were performed and 123 of them were operated. Cytological diagnosis of all FNAB is shown below: malignant lesions 17 (1.8 %), Hashimoto thyroiditis 20 (2.1 %), subacute thyroiditis 5 (0.5 %), suspicious follicular proliferation 6 (0.6 %), inadequate specimen 165 (17.0 %) and other benign lesions 755 (80-0 %). Sampling errors and cytodiagnostic errors were calculated as 7,7 % (9/123) and 4.0 % (5/123) respectively. Rates are calculated as false positive 33 %, false negative 3 %, sensitivity 77 %, specificity 95 %, positive predictive value 67 %, negative predictive value 53 % and accuracy 93 %. The technical success, sensitivity, positive predictive value and accuracy rates in our series are compatible with the literature but not in perfect ranges. Our results confirm the accuracy of FNAB in the diagnosis of thyroid malignancies. The primary shortcomings consist of difficulty in obtaining representative smears of the lesion at aspiration and a small number of inaccurate results in predicting the specific histological diagnosis. initial examination by ultrasound and radionuclide imaging results showed that cystic and hot nodules had a lower occurrence of malignant lesions but they were not always benign.
Keywords: Fine needle aspiration biopsy, thyroid nodule, thyroidectomy, ultrasonography, radionuclide imaging