ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
REVIEW

Endocrine Effects of Coffee Consumption
Kahvenin Endokrin Etkileri
Received Date : 18 Oct 2019
Accepted Date : 30 Jan 2020
Available Online : 13 Feb 2020
Doi: 10.25179/tjem.2019-71878 - Makale Dili: EN
Turk J Endocrinol Metab 2020;24:72-86
Bu makale, CC BY-NC-SA altında lisanslanmış açık erişim bir makaledir.
ABSTRACT
Caffeine has been found to exert various biological effects including, antiangiogenic, antiproliferative, antimetastatic activity, increased fat oxidation and mobilization of glycogen in muscle, increased lipolysis, and reduction of body fat. The aim of this review is to analyze the endocrine effects of coffee consumption. A systematic literature search was conducted on PubMed and Web of Science databases seeking articles published until May 2019, dealing with coffee consumption and diabetes, osteoporosis, thyroid gland, adrenal, and gonads. The results of the most epidemiologic studies reported that coffee consumption has positive effects on combating type 2 diabetes risk, has no significant effects on bone mineral density levels but fracture risk was shown to be higher in the high coffee consumer group. Coffee intake has no significant effect on thyroid cancer, increases sex hormone binding globulin levels, has no effect on fertility but higher consumption was related to spontaneous abortion. Studies pertaining to coffee consumption and endocrine effects have contrary results. More randomized clinical studies with a long term follow up period are required.
ÖZET
Kafeinin; antiproliferatif, antianjiyogenik, antimetastatik etkileri, artmış yağ oksidasyonu, glikojenin kas içinde mobilizasyonu, artmış lipoliz gibi çeşitli biyolojik etkileri gösterilmiştir. Bu çalışmada amacımız, kahve tüketiminin endokrin sistem üzerine olan etkilerini incelemektir. Mayıs 2019'a kadar kahve tüketimi ve diyabet, osteoporoz, tiroid hastalıkları, adrenal ve gonad fonksiyonları hakkında yayımlanan makaleler PubMed ve Web of Science veri tabanlarında sistematik olarak tarandı. Epidemiyolojik çalışmalar, kahve tüketiminin Tip 2 diyabet riskini azaltmada olumlu etkisi olduğunu, kemik mineral yoğunluğu üzerinde anlamlı bir etkisinin olmadığını, ancak yüksek kahve tüketen grupta kırık riskinin daha yüksek olduğunu, tiroid kanseri üzerinde anlamlı etkisinin olmadığını, seks hormon bağlıyıcı globulin seviyelerini arttırdığı, doğurganlık üzerine etkisi olmadığını, ancak spontan abortus riskini artırdığını göstermiştir. Kahve tüketimi ve endokrin etkiler üzerine yapılan çalışmaların çelişkili sonuçları olup net etkilerini belirleyebilmek için uzun takip süreli klinik çalışmalar gereklidir.
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