ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism
ORIGINAL ARTICLE

Demographic and Clinical Features of Medullary Thyroid Carcinoma
Medüller Tiroid Karsinomunun Demografik ve Klinik Özellikleri
Received Date : 31 Jul 2019
Accepted Date : 04 Sep 2020
Available Online : 30 Sep 2020
Doi: 10.25179/tjem.2019-66818 - Makale Dili: EN
Turk J Endocrinol Metab. 2020;24:253-260
Bu makale, CC BY-NC-SA altında lisanslanmış açık erişim bir makaledir.
ABSTRACT
Objective: Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor affecting the parafollicular C cells of the thyroid gland. This study aimedto analyze demographic and clinical factors that might affect the prognosis of MTC andevaluate the long-term outcomes of surgery in MTC patients at a single center. Material and Methods: A total of 36 patients with a confirmed MTC diagnosis based on histopathological examination and underwent surgeryduring 2000–2015 were examined. Archived files of these patients were reviewed, and data on clinical, biochemical, and radiological test results were assessed. Factors affecting disease-free survival were also evaluated. Results: Theduration of the follow-up of the patients was 80.3±76.1 months. MEN2A was detected in three patients (8.3%). Twelve patients (33.3%) had metastasis at the time of diagnosis. During the follow-up period, local recurrence was observed in 13 (36.1%) patients. Nine patients (25%) presented metastasis at follow-up. The mean disease-free survival was high in sporadic MTC compared to hereditary MTC. Conclusion: The study observed asignificant contribution tothe hereditary nature of the disease on prognosis. However, other prognostic factors such as gender, nodule characteristics, recurrence and metastasis, and treatment modalities did differsignificant. Patients with MTC should be evaluated to know if the disease is sporadic or hereditary. The small sample size in this study restricts the power of statistical analysis;therefore, further prospective studies are necessary to reveal the other contributory prognostic factors in MTC.
ÖZET
Amaç: Medüller tiroid karsinom (MTK), tiroid bezinin parafoliküler C hücrelerinin nadir görülen agresif seyirli bir nöroendokrin tümörüdür. Çalışmanın amacı, merkezimizde opere olan MTK’lı hastalarda prognozu etkileyen demografik ve klinik faktörleri analiz etmek ve hastalığın uzun dönem sonuçlarını değerlendirmektir. Gereç ve Yöntemler: Çalışmamıza, merkezimizde 2000-2015 yılları arasında opere olup postoperatif histopatolojik değerlendirmede MTK tanısı alan toplam 36 hasta dâhil edildi. Tüm hastaların arşiv dosyaları gözden geçirildi ve klinik, biyokimyasal ve radyolojik verileri incelendi. Hastalıksız sağ kalımı etkileyen faktörler analiz edildi. Bulgular: Çalışmamızda hastaların ortalama takip süresi 80.3±76.1 aydı. Üç hastada (%8,3) MEN2A mevcuttu. On iki hastada (%33,3) tanı anında metastaz vardı. Takip süresince hastaların 13’ünde (%36,1) lokal nüks gözlendi. Dokuz hastada (%25) izleminde metastaz geliştiği görüldü. Ortalama hastalıksız sağ kalım, kalıtsal MTK ile karşılaştırıldığında sporadik MTK'da yüksekti. Sonuç: Çalışmamızda, kalıtsal hastalığın varlığının prognoza önemli katkısı olduğu saptandı. Bununla birlikte, cinsiyet, nodül özellikleri, nüks, metastaz varlığı ve tedavi yöntemleri gibi diğer faktörlerin prognoz üzerinde anlamlı bir farka yol açmadığı gözlendi. MTK’lı hastalar, hastalığın sporadik veya kalıtsal olup olmadığı açısından değerlendirilmelidir. Çalışmamızdaki az sayıda hasta istatistiksel analizin gücünü kısıtladığından, MTK’ya katkıda bulunan prognostik faktörleri saptamak için prospektif çalışmalara ihtiyaç duyulmaktadır.
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