CASE REPORT
Cranium Metastasis: An Unusual Presentation of Differentiated Thyroid Carcinoma
Kranyum Metastazı: Diferansiye Tiroid Karsinomunun Nadir Görülen Bir Prezentasyonu
Ayşe Kubat Üzüm1, Sema Çiftçi Doğansen2, Bülent Canbaz3, Nida Öztop4, Abdurrahman Demir5, Ferihan Aral6
1İstanbul University Medical Faculty, Department of Internal Medicine, Division of Endocrinology and Metabolism, İstanbul, Turkey
2İstanbul University Medical Faculty, Department of Internal Medicine, Division of Endocrinology and Metabolism, İstanbul, Turkey
3İstanbul University Medical Faculty, Department of Internal Medicine, Division of Endocrinology and Metabolism, İstanbul, Turkey
4İstanbul University Medical Faculty, Department of Internal Medicine, İstanbul, Turkey
5İstanbul University Medical Faculty, Department of Internal Medicine, İstanbul, Turkey
6İstanbul University Medical Faculty, Department of Internal Medicine, Division of Endocrinology and Metabolism, İstanbul, Turkey
Doi: 10.4274/Tjem.2258 - Makale Dili: EN
ABSTRACT
Distant metastasis may be the initial sign of differentiated thyroid carcinoma in rare cases. In this instance, the treatment approach is usually individualized. Unlike most other cancers, local treatment of the primary tumor (total thyroidectomy) is preferred as ablative surgery; so that radioactive iodine therapy should be more effective. Repeated doses of I-131 and radiotherapy for metastatic lesions may be needed. We report a female who presented with bone metastasis with fatal progression. Turk Jem 2013; 17: 71-4
Keywords: Differentiated thyroid carcinoma, bone metastasis, radioactive iodine treatment
ÖZET
Nadiren diferansiye tiroid karsinomunun ilk bulgusu uzak metastaz olabilir. Bu durumda tedavi yaklaşımı bireysel olmalıdır. Diğer kanserlerden farklı olarak primer tümörün çıkarılması (total tiroidektomi) cerrahi ablasyon amacı ile tercih edilir, böylece radyoaktif iyot tedavisi daha etkili olabilir. Metastatik lezyonlara yönelik tekrarlayan I-131 tedavisi ve radyoterapi gerekebilir. Kemik metastazı ile prezente olup fatal progresyon gösteren bir kadın hasta sunulmuştur. Turk Jem 2013; 17: 71-4
Anahtar Kelimeler: Diferansiye tiroid karsinomu, kemik metastazı, radyoaktif iyot tedavisi