ORIGINAL ARTICLE

Comparison of Mental Health and Quality of Life in Euthyroid Patients Under Levothyroxine Mono-therapy Based on the Causes of Hypothyroidism
Levotiroksin Monoterapisi Alan Ötiroid Hastalarda Ruh Sağlığı ve Yaşam Kalitesinin Hipotiroidi Nedenlerine Göre Karşılaştırılması
Received Date : 16 Mar 2021
Accepted Date : 05 Jul 2021
Available Online : 20 Aug 2021
Doi: 10.25179/tjem.2021-83124 - Makale Dili: EN
Turk J Endocrinol Metab. 2021;25:288-294
Bu makale, CC BY-NC-SA altında lisanslanmış açık erişim bir makaledir.
ABSTRACT
Objective: A controversy prevails regarding the adequacy of levothyroxine treatment in hypothyroid patients to reduce the risk of psychiatric illness, mood disorders and improve their quality of life. This study evaluated the relationship between different causes of hypothyroidism, mental health, and quality of life in patients treated with levothyroxine. Material and Methods: This cross-sectional study was performed on three groups of hypothyroid patients (Hashimoto thyroiditis, thyroidectomy, radioiodine therapy) treated with levothyroxine for at least six months, with the last thyroid-stimulating hormone within the normal range. After recording the demographic characteristics and thyroid hormone profiles, quality of life [12-item Short-Form Health Survey (SF-12)] and mental health [General Health Questionnaire 28 (GHQ-28)] were evaluated. Results: A total of 109 patients were evaluated in 3 groups of Hashimoto (48 patients), radioiodine therapy (15 patients), and thyroidectomy (46 patients). No significant difference was found between the 3 groups as evaluated by the total score of the SF-12 and GHQ- 28 questionnaires. The FT3/FT4 ratio was significantly correlated with five variables related to mental health and quality of life. Conclusion: The study did not find any association between the cause of hypothyroidism and psychological symptoms. However, a possible association between psychological symptoms and thyroid function status is suggested.
ÖZET
Amaç: Hipotiroid hastalarda levotiroksin tedavisinin psikiyatrik hastalık ve duygudurum bozuklukları riskini azaltmadaki ve yaşam kalitesini iyileştirmedeki yeterliliği konusunda bir tartışma söz konusudur. Bu çalışmada, levotiroksin ile tedavi edilen hastalarda hipotiroidizmin farklı nedenleri, ruh sağlığı ve yaşam kalitesi arasındaki ilişki değerlendirilmiştir. Gereç ve Yöntemler: Bu kesitsel çalışma, en az 6 ay boyunca levotiroksin ile tedavi edilen ve son tiroid uyarıcı hormon değeri normal aralıkta olan 3 grup hipotiroid hasta (Hashimoto tiroiditi, tiroidektomi, radyoiyot tedavisi) üzerinde yapıldı. Demografik özellikler ve tiroid hormon profilleri kaydedildikten sonra yaşam kalitesi [Kısa Form-12 (12-item Short-Form Health Survey “SF-12”)] ve ruh sağlığı [Genel Sağlık Anketi-28 (General Health Questionnaire 28 “GHQ-28”)] değerlendirildi. Bulgular: Hashimoto (48 hasta), radyoiyot tedavisi (15 hasta) ve tiroidektomi (46 hasta) olmak üzere 3 grupta toplam 109 hasta değerlendirildi. SF-12 ve GHQ- 28 anketlerinin toplam puanı ile değerlendirilen 3 grup arasında anlamlı bir fark bulunmadı. FT3/FT4 oranı ise ruh sağlığı ve yaşam kalitesi ile ilişkili 5 değişkenle anlamlı şekilde korele idi. Sonuç: Çalışmada, hipotiroidizmin nedeniyle psikolojik belirtiler arasında herhangi bir ilişki bulunamamıştır. Bununla birlikte, psikolojik semptomlar ile tiroid fonksiyon durumu arasında bir ilişki söz konusu olabilir.
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