CASE REPORT
Coexistence of Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid and Papillary Thyroid Microcarcinoma in a Background of Hashimoto’s Thyroiditis
Hashimoto Tiroiditi Zemininde Tiroidin Primer Mukoza İlişkili Lenfoması ve Papiller Mikrokarsinom Birlikteliği
Received Date : 04 Sep 2019
Accepted Date : 29 Dec 2019
Available Online : 16 Jan 2020
Hakan DÜGER, Murat ÇALAPKULU, Bekir UÇAN, Erman ÇAKAL*, Mustafa ÖZBEK*, Demet YILMAZER*, Kutsal DOĞAN*, Muhammed Erkam SENCAR
University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey
*University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Pathology, Ankara, Turkey
Doi: 10.25179/tjem.2019-71318 - Makale Dili: EN
Turk J Endocrinol Metab 2020;24:92-95
ABSTRACT
Papillary thyroid carcinoma (PTC) is the most common endocrine
cancer; however, extranodal marginal zone
lymphoma of the mucosa-associated lymphoid tissue
(MALT) of the thyroid gland is quite rare. The comorbid condition
of both cancers is an infrequent event. In the present
study, we report a 65-year-old woman, who underwent a
thyroid ultrasound examination due to palpable thyroid nodules.
The reports of the thyroid ultrasound revealed thyroiditis
and the presence of multiple nodules on both lobes.
Although the results revealed that biopsies were benign,
total thyroidectomy was performed due to the presence of
multiple nodules that may become difficult for the subsequent
follow-up. Histopathological analysis exhibited the
presence of papillary thyroid microcarcinomas in two foci,
Hashimoto’s thyroiditis accompanied with MALT lymphoma.
No metastasis was found in postoperative computed tomography
(CT) scans. However, bone marrow biopsy indicated
uniform marginal zone lymphoma. From the result, it
can be concluded that PTC and Primary Thyroid Lymphoma
(PTL) may be associated with Hashimoto’s thyroiditis, and
for both the diseases multimodal approach is required.
Keywords: Papillary thyroid carcinoma; lymphoma; Hashimoto’s thyroiditis
ÖZET
Papiller tiroid karsinomu (PTC) en yaygın endokrin kanserdir;
bununla birlikte tiroid bezinin mukoza ile ilişkili lenfoid
dokusunun (MALT) ekstranodal marjinal zon lenfoması oldukça
nadirdir. Her iki kanserin eşlik eden durumu nadir görülen
bir durumdur. Bu çalışmada, ele gelen tiroid nodülleri
nedeniyle tiroid ultrasonu yapılan 65 yaşında bir kadın hastayı
sunduk. Tiroid ultrasonunda tiroidit ve her iki lobda birden
fazla nodül saptandı. Biyopsi sonuçları benign olmasına
rağmen, nodül sayısının çok olmasına bağlı takip zorluğu nedeniyle
total tiroidektomi yapıldı. Histopatolojik analiz, Hashimoto
tiroiditi zemininde MALT lenfomaya eşlik eden iki
odakta papiller tiroid mikrokarsinomu varlığını gösterdi. Postoperatif
bilgisayarlı tomografi (BT) taramalarında metastaz
saptanmadı. Bununla birlikte, kemik iliği biyopsisinde
marjinal zon lenfoma saptandı. Sonuç olarak, PTC ve Primer
Tiroid Lenfomasının (PTL) Hashimoto tiroiditi ile ilişkili olabileceği
ve her iki hastalık için de multimodal yaklaşımın gerekli
olduğu sonucuna varılabilir.
Anahtar Kelimeler: Papiller tiroid karsinomu; lenfoma; Hashimoto tiroiditi
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