ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism

Retroperitoneal Castleman Disease Mimicking Paraganglioma in a Patient with Klinefelter Syndrome: A Case Report
Klinefelter Sendromlu Bir Hastada Paragangliomayı Taklit Eden Retroperitoneal Castleman Hastalığı: Bir Olgu Sunumu
Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey *Department of Pathology, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey **Department of General Surgery, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
Doi: 10.25179/tjem.2019-64815 - Makale Dili: EN
Turk J Endocrinol Metab
ABSTRACT
Castleman disease progresses with the enlargement of the affected lymph nodes and represented by a wide range of symptoms. This lymphoproliferative disease rarely affects the retroperitoneum. A patient with Klinefelter syndrome was admitted to our clinic following palpitation and sweat attacks. It was observed that the urinary catecholamine metabolites were elevated and a pararenal mass was found on the left side. The patient was directed to surgery with the paraganglioma pre-diagnosis after further examination. Histopathological examination of the excised mass confirmed the diagnosis of Castleman disease. The urinary catecholamine metabolites returned to near-normal levels at eight weeks after the surgery. We present a case of Castleman disease in a patient with Klinefelter syndrome, imitating paraganglioma as per the clinical, radiological and laboratory findings.
ÖZET
Castleman hastalığı, etkilenen lenf nodunda büyüme ile ortaya çıkar ve birçok farklı semptomla kendini gösterebilir. Bu lenfoproliferatif hastalık nadiren retroperitoneumu etkiler. Klinefelter sendromlu bir hasta kliniğimize çarpıntı ve terleme atakları ile başvurdu. İdrar katekolamin metabolitlerinin yükselmiş olduğu gözlenip sol pararenal bölgede bir kitle tespit edildi. İleri tetkik edilen hasta paraganglioma ön tanısı ile cerrahiye yönlendirildi. Eksize edilen kitlenin histopatolojik değerlendirme sonucu Castleman hastalığı tanısını doğruladı. Olgunun idrar katekolamin metabolitleri cerrahi sonrası sekizinci haftada normale yakın seviyelere geriledi. Bu olgu sunumunda Klinefelter sendromlu bir hastada klinik, radyolojik ve laboratuar bulguları ile paragangliomayı taklit eden bir Castleman hastalığı vakası sunduk.