ISSN: 1301-2193 E-ISSN: 1308-9846
  • Turkish Journal of
    Endocrinology and Metabolism

Determination of Serum Thyroid Hormones and Electrolytes in Hypothyroid and Hyperthyroid Females-A Case Control Study in Lahore, Pakistan
Hipotiroid ve Hipertiroid Kadınlarda Serum Tiroid Hormonları ve Elektrolitlerinin Belirlenmesi-Lahor, Pakistan'da Bir Vaka Kontrol Çalışması
University Institute of Medical Laboratory Technology, The University of Lahore, Lahore, Pakistan
Doi: 10.25179/tjem.2018-63502 - Makale Dili: EN
Turk J Endocrinol Metab 2019;23:19-24
ABSTRACT
Objective: This study aimed to determine the correlation between serum electrolytes and TSH in patients with hypothyroidism and hyperthyroidism. Material and Methods: A total of 160 (80 hypothyroid and 80 hyperthyroid) patients and 80 age and gender matched controls were enrolled in this study, which was performed between September 2017-February 2018. Of the venous blood, 3 mL was collected from each study participant, for measurement of thyroid hormones (T3, T4, and TSH) and electrolytes (Na, K and Ca). Results: Serum calcium was observed to be significantly high in hyperthyroid patients as compared to their controls. Serum sodium and potassium levels were not found to differ significantly among hyperthyroid and hypothyroid patients compared to that in their controls. Patients with hyperthyroidism showed significant negative correlation of TSH with calcium and a non-significant positive correlation with sodium and potassium. The correlation of TSH with calcium was positive while that with potassium and sodium was negative in hypothyroid patients, though this co-relation was statistically non-significant. Conclusion: This study found high serum calcium levels in hyperthyroid patients. A significantly negative correlation was found between TSH and calcium level in hyperthyroidism.
ÖZET
Amaç: Bu çalışmada, hipotiroidi ve hipertiroidi hastalarında serum elektrolitleri ve TSH arasındaki korelasyonun belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Eylül 2017-Şubat 2018 tarihleri arasında yapılan bu çalışmaya, toplam 160 (80 hipotiroidi ve 80 hipertiroidi) hasta ile yaş ve cinsiyeti eşleştirilmiş 80 kontrol dâhil edildi. Tiroid hormonlarının (T3, T4 ve TSH) ve elektrolitlerinin (Na, K ve Ca) ölçümü için her bir katılımcıdan 3 mL venöz kan alındı. Bulgular: Hipertiroidili hastalarda serum kalsiyumun kontrollerine göre anlamlı derecede yüksek olduğu gözlendi. Serum sodyum ve potasyum düzeylerinin, hipertiroidi ve hipotiroidi hastaları arasında kontrollerine göre anlamlı derecede farklı olmadığı bulundu. Hipertiroidi hastalarında TSH ile kalsiyum arasında anlamlı negatif korelasyon, sodyum ve potasyum ile anlamlı olmayan pozitif korelasyon saptandı. Hipotiroidi hastalarında TSH’nin kalsiyum ile korelasyonu pozitif, potasyum ve sodyum ile korelasyonu negatif idi ama bu korelasyonlar istatistiksel olarak anlamlı değildi. Sonuç: Bu çalışmada, hipertiroidili hastalarda serum kalsiyum seviyelerinin yüksek olduğu bulundu. Hipertiroidizmde TSH ile kalsiyum düzeyi arasında anlamlı bir negatif korelasyon olduğu görüldü.
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